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Exercise training as S-Klotho protein stimulator in sedentary healthy adults


S-Klotho is considered a potent biomarker of longevity and has several functions in anti-aging, such as the regulation of calcium metabolism and phosphate metabolism (reducing apoptosis cell death), also, reduces the inflammatory process and oxidative stress , protecting cells from oxidative stress. In this way an anti-aging effect is obtained.

Several studies have reported that exercise induces the activation of several factors that also increase the expression of the α-Klotho gene. One of the studies showed that aerobic exercise training increased plasma S-Klotho levels in postmenopausal women.


80 participants will be assigned in four groups: Physical activity recommendation group (n = 20), HIIT group (n = 20), whole body electrostimulation group (WB-EMS) (n = 20) and control group.

Physical activity recommendation group:

HIIT group:

WB-EMS group:

Control group:

General advice will be given to the participants of the control group through an informational meeting chaired by a graduate in Sports Science. They will be instructed to maintain their lifestyle.


The primary outcome of this study is the plasma levels of S-Klotho. Secondary outcome variables include physical fitness components, body composition and anthropometric measurements, energy expenditure and nutrient oxidation, heart rate variability (HRV), blood biomarkers, physical activity of free life, cognitive variables, quality of life. related to health, dietary habits and risk factors for cardiovascular disease in sedentary healthy adults.


The α-Klotho gene correlates positively with a longer life, and the lack of this α-Klotho gene is related to aging phenotypes such as arteriosclerosis, decreased bone mineral density, sarcopenia, skin atrophy. and cognitive impairment. Anti-aging effects similar to exercise and physical activity have also been attributed. Therefore, α-Klotho and physical activity are factors that can promote the improvement of older people’s abilities and their relationship has been demonstrated in scientific studies.


Francisco J. Amaro-Gahete., Alejandro De-la-O., Lucas Jurado-Fasoli., Andrea Espuch-Oliver., Lidia Robles-Gonzalez., Ginés Navarro-Lomas., Tomás de Haro., Pedro Femia., Manuel J. Castillo. and Angel Gutierrez. Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology. (2018). Contemp Clin Trials Commun. 11: 10–19.

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